1/19/2024 0 Comments Grapefruit juice and xanax52, 311–315.ĭresser GK, Bailey DG & Carruthers SG (2000): Grapefruit juice–felodipine interaction in the elderly. 4, 313–321.Ĭlifford CP, Adams DA, Murray S, Taylor GW, Wilkins MR, Boobis AR & Davies DS (1997): The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice. 129, 1655–1667.īrunner LJ, Pai KS, Munar MY, Lande MB, Olyaei AJ & Mowry JA (2000): Effect of grapefruit juice on cyclosporin A pharmaco-kinetics in pediatric renal transplant patients. Transplant 16, 373–377.īohets H, Lavrijsen K, Hendrickx J, van Houdt J, van Genechten V, Verboven P, Meuldermans W & Heykants J (2000): Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactions. 59, 383–388.īistrup C, Nielsen FT, Jeppesen UE & Dieperink H (2001): Effect of grapefruit juice on sandimmun neoral absorption among stable renal allograft recipients. Lancet 337, 268–269.īenton RE, Honig PK, Zamani K, Cantilena LR & Woosley RL (1996): Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram. 12, 357–362.īailey DG, Spence JD, Munoz C & Arnold JM (1991): Interaction of citrus juices with felodipine and nifedipine. 46, 101–110.īailey DG, Spence JD, Edgar B, Bayliff CD & Arnold JM (1989): Ethanol enhances the hemodynamic effects of felodipine. 68, 468–477.īailey DG, Malcolm J, Arnold O & Spence JD (1998): Grapefruit juice–drug interactions. 54, 589–594.īailey DG, Dresser GK, Kreeft JH, Munoz C, Freeman DJ & Bend JR (2000): Grapefruit–felodipine interaction: effect of unprocessed fruit and probable active ingredients. 53, 637–642.īailey DG, Arnold JM, Strong HA, Munoz C & Spence JD (1993b): Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. 40, 135–140.īailey DG, Arnold JM, Munoz C & Spence JD (1993a): Grapefruit juice–felodipine interaction: mechanism, predictability, and effect of naringin. It is likely that more information regarding this interaction will accumulate in the future, and awareness of such is necessary for achieving optimal drug therapy.īailey DG, Arnold JM, Bend JR, Tran LT & Spence JD (1995): Grapefruit juice–felodipine interaction: reproducibility and characterization with the extended release drug formulation. The data available so far, concerning this interaction and its clinical implications, are reviewed in this article. A single exposure to one glass of the juice can usually produce the maximal magnitude of the interaction. Some calcium channel antagonists, benzodiazepines, HMG-CoA reductase inhibitors and cyclosporine are the most affected drugs. An additional mechanism is, presumably, the inhibition of P-glycoprotein, a transporter that carries drug from the enterocyte back to the gut lumen, resulting in a further increase in the fraction of drug absorbed. The predominant mechanism for this interaction is the inhibition of cytochrome P-450 3A4 in the small intestine, resulting in a significant reduction of drug presystemic metabolism. The coadministration of these drugs with grapefruit juice can markedly elevate drug bioavailability, and can alter pharmacokinetic and pharmacodynamic parameters of the drug. More than a decade has passed since it was unintentionally discovered that grapefruit juice interacts with certain drugs.
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